Q: Does Estradiol cause weight gain? A: Possibly. While weight gain is a possible side effect of any hormone, I have not heard very many woman complain about estrogens causing weight gain. Estrace vaginal cream is a preparation of estrogen, a female hormone, for topical application to the vaginal area used to treat certain symptoms of menopause such as dryness, burning, and itching of the vaginal area and urgency or irritation with urination. Easy-to-read patient leaflet for Estrace (Estradiol Vaginal Cream). Includes indications, proper use, special instructions, precautions, and possible side effects. Includes indications, proper use, special instructions, precautions, and possible side effects. How to use Estrace Cream With Applicator. Read the Patient Information Leaflet if available from your pharmacist before you start using this medication and each time you get a refill. Our Estrace (estradiol) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. This is not a complete list of side effects and others may occur. Along with its needed effects, estradiol may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Although not all of these side effects may occur, if they do occur they may need medical attention. How to use Estrace. Read the Patient Information Leaflet if available from your pharmacist before you start using this medication and each time you get a refill. I have fibromyalgia, and there are quite a few trigger points on my body. These trigger points hurt a ton when pressure is put on them.I tried an estrogen birth control and that gave me nasty migraines. Can Estradiol cause Sinus Headaches? Complete analysis from patient reviews and trusted online health resources, including first-hand experiences. Complete analysis from patient reviews and trusted online health resources, including first-hand experiences. Will you have Headache with Estrace - from FDA reports Summary Headache is found among people who take Estrace, especially for people who are female, 60+ old , have been taking the drug for 1 month, also take medication Synthroid, and have Pain.